Research and Development

Rebasol

An anti-adhesive gel that prevents the formation of postoperative adhesions without any adverse effects on wound healing, is being developed. Rebasol's composition is innovative. It is a bioresorbable product consisting of ultrapure alginate and poly-dextran sulphate. The muco-adherent properties of the gel allow it to remain in place even in gravitationally dependent areas. The product will also be easy to apply in both laparotomy and laparoscopy procedures and will be able to achieve a broad coverage of anatomic sites to prevent postoperative adhesion formation.

Preclinical Animal study data

Preclinical animal experimental studies performed with Rebasol gel indicates its efficacy in preventing adhesion formation and also its safety in regards to use of the gel on the presences of anastomosis.

Prevention of postsurgical adhesions using an ultrapure alginate-based gel.
Chaturvedi AA, Lomme RM, Hendriks T, van Goor H.
Br J Surg. 2013 Jun;100(7):904-10. doi: 10.1002/bjs.9131.
PMID: 23592329

Ultrapure alginate gel reduces adhesion reformation after adhesiolysis.
Chaturvedi AA, Lomme RM, Hendriks T, van Goor H.
Int J Colorectal Dis. 2014 Nov;29(11):1411-6. doi: 10.1007/s00384-014-2009-5.
PMID: 25213585

Ultrapure alginate anti-adhesion gel does not impair colon anastomotic strength.
Chaturvedi AA, Lomme RM, Hendriks T, van Goor H.
J Surg Res. 2014 Jun 4. pii: S0022-4804(14)00548-4. doi: 10.1016/j.jss.2014.05.085.
PMID: 24980857

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