Human Bone Allografts
Allografts are human donor tissues (e.g. bone) processed for use in various surgical procedures (e.g. spinal, pelvic and fracture non-union). These products are cleaned with super critical gas extraction, processed and sterilised at the end of the process. The total process reduces the risk of transmitting diseases by eliminating virtually all lipids, protein and potential transmissible agents. Examples of allograft products include products from pre-formed bone segments for applications such as spinal fusions and granules for bone void filling.
Demineralised bone matrix is to be developed as an additional bone filler and is a spin off from human bone products purified with super critical gas extraction. It is known from literature that demineralisation can result in exposing matrix-encapsulated bone morphogenetic protein, or BMP. In this manner, the osteoinductivity of the existing human bone product may be increased tremendously.
Main advantages include:
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Lower risk of transmitting diseases than the products currently available
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Straightforward method fulfilling the recent validation standards as required by
competent authorities -
Mechanical properties of the bone do not change, due the absence of solvent
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Increased osteoinductivity
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Adaptation of existing production process.
